Intravenous immunoglobulin treatment in paraneoplastic neurological syndromes with antineuronal autoantibodies.
نویسندگان
چکیده
منابع مشابه
Treatment of paraneoplastic neurological syndromes with antineuronal antibodies (Anti-Hu, anti-Yo) with a combination of immunoglobulins, cyclophosphamide, and methylprednisolone.
OBJECTIVES To evaluate the effect of a combination of immunoglobulins (IVIg), cyclophosphamide (CTX), and methylprednisolone (MP) on the clinical course of patients with paraneoplastic neurological syndrome (PNS) and antineuronal antibodies (Abs). METHODS Seventeen patients with paraneoplastic encephalomyelitis/sensory neuropathy (PEM/SN) with anti-Hu Abs (n = 10) or cerebellar degeneration (...
متن کاملParaneoplastic neurological syndromes: diagnosis and treatment.
PURPOSE OF REVIEW The most relevant advances in the field of paraneoplastic neurological syndromes are described, with special emphasis on particular clinical-immunological associations and practical issues for the diagnosis and treatment of these disorders. RECENT FINDINGS Paraneoplastic neurological syndromes may present with classical neurological symptoms or less frequently with symptoms ...
متن کاملParaneoplastic neurological syndromes
Necrobiotic xanthogranuloma This presents as multiple sharply demarcated, indurated, non-tender dermal or subcutaneous nodules and plaques. Periorbital involvement is common. Lesions vary from violaceous to red orange, and enlarge to form infiltrative plaques that may show central atrophy. Though most of the lesions are asymptomatic, some may be pruritic or painful. Ulceration and scarring are ...
متن کاملParaneoplastic neurological syndromes
Paraneoplastic neurological syndromes are immune-mediated erroneous attacks on the central or peripheral nervous systems, or both, directed originally against the tumour itself. They have been known for more than 40 years, but recently the discovery of new subgroups of paraneoplastic encephalitis syndromes with a remarkably good response to immune therapy has ignited new clinical and scientific...
متن کامل[Paraneoplastic neurological syndromes].
BACKGROUND Paraneoplastic neurological syndromes constitute a heterogenous group of diseases, which often cause severe neurological symptoms. Extensive research during the last 20 years has led to identification of new antigenic targets and inclusion of additional clinical conditions into this group of syndromes. MATERIAL AND METHODS The article is based on a non-systematic search of PubMed a...
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ژورنال
عنوان ژورنال: Journal of Neurology, Neurosurgery & Psychiatry
سال: 1996
ISSN: 0022-3050
DOI: 10.1136/jnnp.60.4.388